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Key Takeaways
- GobyMeds lists testosterone injections, cream and a needle-free hypospray from $133 a month, enclomiphene from $99 on a six-month plan, and sermorelin from $199 for one month ($399 for three). Lab work is billed separately.
- Testosterone therapy is meant for men with symptoms and testosterone that’s low on repeated morning blood tests.
- Sermorelin’s evidence in older men is a few small studies from the 1990s. It has never been FDA-approved for anti-aging, muscle or fat loss.
- Weight loss is the one with evidence behind it for raising testosterone. Sleep and lifting are good for you regardless.
A lot of men over 50 find GobyMeds through its GLP-1 pricing, then notice the rest of the menu: testosterone and sermorelin. Both get sold on energy, muscle and drive.
That’s the pitch to slow down on. Here’s what GobyMeds actually lists, what the research does and doesn’t show, and what a careful prescriber should check first. It’s not medical advice. It’s the homework to do before you talk to one. Talk to your own prescriber before you start, stop or change anything.
What Testosterone Options Does GobyMeds Offer?
As of October 2026, GobyMeds lists four testosterone products. Testosterone cypionate, a once-weekly self-injection, starts at $133 a month. A daily cream starts at $149 and a needle-free hypospray at $166.
The fourth is enclomiphene, a daily capsule meant to prompt your body to make more of its own testosterone. The site positions it for men who want to protect fertility.
The replacement products are listed for men 35 and up with lab-confirmed low testosterone. Labs cost extra: a flat $115 per lab session, with labs every 90 days. You can see GobyMeds’ current testosterone lineup and pricing here.
One question to ask at intake: is my product compounded? Compounded drugs aren’t FDA-approved, and the agency doesn’t verify their safety, effectiveness or quality before they’re sold. GobyMeds says as much on its own testosterone page: compounded testosterone products and enclomiphene are not FDA-approved.
For the platform itself, meaning cost, shipping and whether it’s legit, see our GobyMeds review.
What Is Enclomiphene, and Does It Work?
Enclomiphene is the option that isn’t testosterone. GobyMeds describes the daily capsule as prompting your pituitary gland to signal for more of your own testosterone. It lists it at $349 for three months ($116 a month) or $599 for six months ($99 a month).
The best-known evidence is two phase III trials in overweight men aged 18 to 60 with secondary hypogonadism, meaning the signal from the brain is the problem. Over 16 weeks, enclomiphene raised total testosterone and kept sperm concentration in the normal range. Sperm counts fell markedly in the men using testosterone gel.
Two cautions. Those trials ran 16 weeks and stopped at age 60, so they can’t tell a 58-year-old what year three looks like. And the regulatory picture is unsettled. In 2022 an FDA advisory committee voted 8 to 4 against putting enclomiphene citrate on the list of bulk ingredients pharmacies can compound with. Several members who voted no pointed to a lack of clinical efficacy evidence. FDA’s list, updated May 2026, carries it in Category 1, substances under evaluation.
What Is Sermorelin?
Sermorelin is the active fragment of growth hormone releasing hormone, the first 29 amino acids of it. That’s the signal your brain uses to tell the pituitary gland to release growth hormone.
It doesn’t replace growth hormone. It nudges your pituitary to make more. GobyMeds sells it as an injection, oral tablet, dissolving troche or film strip: $199 for one month, or $399 for three months on the injection or troche. The film strip runs $249 and $499.
Is Sermorelin FDA Approved?
Not for anything it’s marketed for today. The FDA-approved sermorelin product was Geref, approved in 1990 as a diagnostic test of pituitary function and in 1997 to treat growth hormone deficiency in children with growth failure.
In 2008 its maker, EMD Serono, told FDA it was discontinuing it. In 2013 the FDA confirmed it wasn’t pulled for safety or effectiveness reasons. It was never approved for aging, muscle, fat loss, sleep or libido in adults.
The sermorelin a telehealth company ships today isn’t Geref, which is no longer sold. It’s a prescription product from a pharmacy, and GobyMeds’ page doesn’t say who makes it. Sermorelin acetate isn’t on FDA’s list of bulk substances nominated for compounding under section 503A (updated May 2026). FDA’s separate 503B list (updated March 2025) carries it in Category 1, substances under evaluation. I found no FDA statement that settles how it may be compounded for patients. So ask the provider plainly: which pharmacy fills this, and is it licensed in my state?
Does Sermorelin Work?
It raises growth hormone signals. Whether that turns into anything you’d notice is where the evidence gets thin.
A 1997 study gave 11 healthy men aged 64 to 76 nightly GHRH injections for six weeks. Nighttime growth hormone went up. Two of six strength measures improved. Muscle and fat on a DEXA scan didn’t change, and neither did IGF-1.
A second 1997 study used a close sermorelin analog for 16 weeks in 9 men and 10 women aged 55 to 71. Lean mass rose in the men only, and IGF-1 drifted back toward baseline by week 16.
That’s 20 men across two small studies, nearly 30 years old. It’s a reason for curiosity, not proof it’ll do anything for you.
The GobyMeds sermorelin page lists muscle growth, fat metabolism and sleep as benefits and doesn’t mention FDA status. It goes further than the studies do. It calls sermorelin a “safe and effective way” to restore growth hormone levels and says full results typically take three to six months. The two studies above ran six and 16 weeks. Neither speaks to month six or to long-term safety.
Does Testosterone Therapy Work for Men Over 50?
For men with genuinely low testosterone and symptoms, it helps with some things and not others. The best evidence is the NIH-funded Testosterone Trials in NEJM (2016): 790 men aged 65 and up, testosterone below 275 ng/dL, one year of gel or placebo.
Testosterone improved sexual activity, desire and erectile function, and gave a small lift in mood. It did nothing measurable for energy, the vitality score. It didn’t improve walking distance in the physical function trial itself.
That matters, because tiredness is why a lot of men go looking. The FDA labeling says the same in its own way: safety and efficacy in “age-related hypogonadism” haven’t been established.
What Counts as Low Testosterone?
There isn’t one magic number. The American Urological Association’s 2018 guideline (Journal of Urology) calls a total testosterone under 300 ng/dL a reasonable cutoff in support of the diagnosis. It says to diagnose low testosterone only after two early-morning total testosterone measurements on separate occasions, and only when low levels come with symptoms or signs.
The Endocrine Society asks for symptoms plus consistently low fasting morning levels. The TRAVERSE heart-safety trial enrolled men under 300 ng/dL who also had symptoms.
GobyMeds lists the symptoms as low energy, reduced sex drive, loss of muscle and strength, brain fog, low mood and poor sleep. Several of those have plenty of other causes, which is why the lab numbers come first.
What Labs Should You Get Before Starting TRT?
The Endocrine Society’s 2018 guideline sets the bar. The guideline calls for these:
- A fasting morning total testosterone, repeated on a second morning to confirm it’s low.
- Free testosterone if your total is borderline or you have a condition that affects SHBG.
- LH and FSH, to see whether the problem starts in the testes or the pituitary.
- Hematocrit, since testosterone raises red blood cell counts.
- PSA plus a prostate risk check, especially for men at higher risk.
After you start, the guideline calls for rechecking symptoms, testosterone, hematocrit and prostate risk during the first year. GobyMeds says it repeats labs every 90 days, which is in line with the guideline’s first-year monitoring. If a provider will prescribe off one number and a quiz, walk away.
What Are the Risks of Testosterone Therapy?
The FDA label is the honest list. It warns about raised blood pressure. In February 2025 the FDA said blood pressure studies confirmed an increase with all testosterone products and required blood pressure language on every testosterone label.
The label also covers rising hematocrit, blood clots in the legs and lungs, prostate enlargement, fluid retention, abuse and suppressed sperm production. If you want more kids, talk about fertility before starting. It’s contraindicated with breast or prostate cancer.
The heart question got real data in 2023. The TRAVERSE trial followed 5,246 men aged 45 to 80 with heart disease or high risk. Heart attacks, strokes and cardiac deaths combined were no higher than placebo, 7.0% versus 7.3%. But atrial fibrillation, acute kidney injury and pulmonary embolism were more common on testosterone.
Prostate risk got a close look too. A 2024 review of the large trials, TRAVERSE included, found low rates of adverse prostate events in men who were screened first to exclude high prostate cancer risk, with no difference from placebo. PSA did rise more on testosterone during the first year, which is why it gets checked.
Who Should Not Start Testosterone Therapy?
The Endocrine Society recommends against starting if you’re planning fertility in the near term or have any of these:
- Breast or prostate cancer.
- A palpable prostate nodule, or a PSA above 4 ng/mL (above 3 in men at higher risk, without further urology evaluation).
- Elevated hematocrit.
- Untreated severe obstructive sleep apnea.
- Severe lower urinary tract symptoms.
- Uncontrolled heart failure.
- A heart attack or stroke within the last six months.
- Thrombophilia, a tendency to form blood clots.
GobyMeds’ own page lists several of the same, including trying to conceive, prostate or breast cancer history, untreated severe sleep apnea, a high red blood cell count and uncontrolled heart failure. Answer the intake questions honestly. They’re there to protect you. If any of these fit you, talk to your prescriber before you order anything.
Should You Try Lifestyle Changes Before TRT?
Yes, for most men. Extra body fat pulls testosterone down, and losing it pushes it back up. A 2013 meta-analysis of 24 studies found weight loss raised testosterone, and the more weight men lost, the bigger the rise.
That’s why the order matters. Weight loss is the one with evidence behind it for raising testosterone. Sleep and lifting are good for you regardless. Our guide to exercise and testosterone for men over 50 covers the training side.
Then retest. If you’re still low with real symptoms, TRT is a reasonable conversation with a prescriber who runs the full panel.
Frequently Asked Questions
Is sermorelin illegal?
Not in the sense of being banned. In 2013 the FDA found that Geref wasn’t withdrawn for safety or effectiveness reasons. Today’s telehealth sermorelin isn’t Geref, and compounded drugs aren’t FDA-approved. FDA’s 503B list carries sermorelin acetate in Category 1, under evaluation, and I found no FDA statement that settles how it may be compounded. Ask which pharmacy fills your order.
Does testosterone therapy cause prostate cancer?
The American Urological Association’s 2018 guideline tells clinicians to inform patients of the absence of evidence linking testosterone therapy to the development of prostate cancer. The 2024 trial review agrees for screened men. Still, the label rules it out if you already have prostate cancer, and PSA can rise.
Does GobyMeds check labs before prescribing testosterone?
Its page says nothing is prescribed on symptoms alone. A baseline panel checks hematocrit, PSA, lipids and estradiol, with follow-up labs every 90 days at $115 a panel. It doesn’t say it repeats the morning testosterone draw or checks LH and FSH, so ask.
Can I take testosterone if I want more children?
The Endocrine Society recommends against starting testosterone if you’re planning fertility in the near term. The FDA label lists suppressed sperm production, and GobyMeds says the same about injections, cream and spray. That’s the reason enclomiphene exists as an option, though its evidence is thinner.
Related Reading
- If you’re on a GLP-1 and worried about muscle more than hormones, start with how to keep muscle on a GLP-1 after 50.
- Weighing where to get any of this prescribed? We put the two platforms side by side in GobyMeds vs ShedRX.
