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Key Takeaways
- GobyMeds lists testosterone injections, cream and a needle-free hypospray from $133 a month, enclomiphene from $99, and sermorelin from $199 for one month ($399 for three). Lab work is billed separately.
- Testosterone therapy is meant for men with symptoms and testosterone that’s low on repeated morning blood tests.
- Sermorelin’s evidence in older men is a few small studies from the 1990s. It has never been FDA-approved for anti-aging, muscle or fat loss.
- Weight loss has good evidence behind it for raising testosterone. Sleep and lifting are good for you regardless.
A lot of men over 50 find GobyMeds through its GLP-1 pricing, then notice the rest of the menu: testosterone and sermorelin. Both get sold on energy, muscle and drive.
That’s the pitch to slow down on. Here’s what GobyMeds actually lists, what the research does and doesn’t show, and what a careful prescriber should check first. It’s not medical advice. It’s the homework to do before you talk to one.
What Testosterone Options Does GobyMeds Offer?
As of September 2026, GobyMeds lists four testosterone products. Testosterone cypionate, a once-weekly injection you give yourself at home, starts at $133 a month. A daily cream starts at $149 and a needle-free hypospray at $166.
The fourth is enclomiphene, a daily capsule meant to prompt your body to make more of its own testosterone, listed at $99+ a month. The site positions it for men who want to protect fertility.
The replacement products are listed for men 35 and up with lab-confirmed low testosterone. Labs cost extra: a flat $115 per lab session, with labs every 90 days. You can see GobyMeds’ current testosterone lineup and pricing here.
One question to ask at intake: is my product compounded? Compounded drugs aren’t FDA-approved, and the agency doesn’t verify their safety, effectiveness or quality before they’re sold.
For the platform itself, meaning cost, shipping and whether it’s legit, see our GobyMeds review.
What Is Sermorelin?
Sermorelin is the active fragment of growth hormone releasing hormone, the first 29 amino acids of it. That’s the signal your brain uses to tell the pituitary gland to release growth hormone.
It doesn’t replace growth hormone. It nudges your pituitary to make more. GobyMeds sells it as an injection, oral tablet, dissolving troche or film strip: $199 for one month, or $399 for three months on the injection or troche. The film strip runs $249 and $499.
Is Sermorelin FDA Approved?
Not for anything it’s marketed for today. The FDA-approved sermorelin product was Geref, approved in 1990 as a diagnostic test of pituitary function and in 1997 to treat growth hormone deficiency in children with growth failure.
Its maker, EMD Serono, stopped selling it in 2008. In 2013 the FDA confirmed it wasn’t pulled for safety or effectiveness reasons. It was never approved for aging, muscle, fat loss, sleep or libido in adults.
The GobyMeds sermorelin page lists benefits like muscle growth, fat metabolism and sleep, and doesn’t mention FDA status. Ask the provider directly whether your sermorelin is compounded.
Does Sermorelin Work?
It raises growth hormone signals. Whether that turns into anything you’d notice is where the evidence gets thin.
A 1997 study gave 11 healthy men aged 64 to 76 nightly GHRH injections for six weeks. Nighttime growth hormone went up. Two of six strength measures improved. Muscle and fat on a DEXA scan didn’t change, and neither did IGF-1.
A second 1997 study used a close sermorelin analog for 16 weeks in 9 men and 10 women aged 55 to 71. Lean mass rose in the men only, and IGF-1 drifted back toward baseline by week 16.
That’s 20 men across two small studies, nearly 30 years old. It’s a reason for curiosity, not proof it’ll do anything for you.
Does Testosterone Therapy Work for Men Over 50?
For men with genuinely low testosterone and symptoms, it helps with some things and not others. The best evidence is the NIH-funded Testosterone Trials in NEJM (2016): 790 men aged 65 and up, testosterone below 275 ng/dL, one year of gel or placebo.
Testosterone improved sexual activity, desire and erectile function, and gave a small lift in mood. It did nothing measurable for energy, the vitality score. It didn’t improve walking distance in the physical function trial itself.
That matters, because tiredness is why a lot of men go looking. The FDA labeling says the same in its own way: safety and efficacy in “age-related hypogonadism” haven’t been established.
What Labs Should You Get Before Starting TRT?
The Endocrine Society’s 2018 guideline sets the bar. A responsible prescriber should order or confirm:
- A fasting morning total testosterone, repeated on a second morning to confirm it’s low.
- Free testosterone if your total is borderline or you have a condition that affects SHBG.
- LH and FSH, to see whether the problem starts in the testes or the pituitary.
- Hematocrit, since testosterone raises red blood cell counts.
- PSA plus a prostate risk check, especially for men at higher risk.
After you start, the guideline calls for rechecking symptoms, testosterone, hematocrit and prostate risk during the first year. GobyMeds’ labs every 90 days fit that. If a provider will prescribe off one number and a quiz, walk away.
What Are the Risks of Testosterone Therapy?
The FDA label is the honest list. It warns about raised blood pressure, and in 2025 the FDA required that warning across every testosterone product after blood pressure studies found increases regardless of how it’s given.
The label also covers rising hematocrit, blood clots in the legs and lungs, prostate enlargement, fluid retention, abuse and suppressed sperm production. Don’t start it if you want more kids without talking about fertility first. It’s contraindicated with breast or prostate cancer.
The heart question got real data in 2023. The TRAVERSE trial followed 5,246 men aged 45 to 80 with heart disease or high risk. Heart attacks, strokes and cardiac deaths were no higher than placebo, 7.0% versus 7.3%. But atrial fibrillation, acute kidney injury and pulmonary embolism were more common on testosterone.
Should You Try Lifestyle Changes Before TRT?
Yes, for most men. Extra body fat pulls testosterone down, and losing it pushes it back up. A 2013 meta-analysis of 24 studies found weight loss raised testosterone, and the more weight men lost, the bigger the rise.
That’s why the order matters. Weight loss has good evidence behind it for raising testosterone. Sleep and lifting are good for you regardless. Our guide to exercise and testosterone for men over 50 covers the training side.
Then retest. If you’re still low with real symptoms, TRT is a reasonable conversation with a prescriber who runs the full panel.
Related Reading
- If you’re on a GLP-1 and worried about muscle more than hormones, start with how to keep muscle on a GLP-1 after 50.
- Weighing where to get any of this prescribed? We put the two platforms side by side in GobyMeds vs ShedRX.
